In Part 2, the gameplay is similar to that of Part 1. You will have to solve puzzles that are almost impossible to solve. However, they always have a very reasonable answer.

There are a total of 120 questions in which, some of them even has several variations of themselves and two different Power-ups. I bet that you will want to have at your disposal. You will have five lives and no checkpoints in this game.  However, you can skip the difficult question and make a return as an actually usable power-up. There is a brand new power-up in this game and called the Fusestopper. It is a small purple one-eyed creature with a special ability is that allows you to disintegrate the returning bombs of the game.

The grade is a gameplay element that allows you to know yourself that how well you performed in this game. It is determined by the lives and/or power-ups that you have after answered the final question. There are total 9 grades in this game including A*, A+, A-, B+, B-, C, D, E, and F. Matching with these grades are the rates perfect, amazing, brilliant, nice one, not bad, average, a bit crap, awful, and bad of shite. And of course, when you finished the game, depending on your grade, you will receive a different comment. For example, if you get the grade A* (required score is 10), you will receive a message: "Oh my God, you're insane! You've not only completed The Impossible Quiz 2, but you've made me weep by finishing it flawlessly... AMAZING!" Very interesting, isn't it?